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2nd DNA Replication as a Source of DNA Damage

July 3 - 6

Join scientific chairs Ian Hickson (University of Copenhagen) and Oscar Fernandez-Capetillo (Karolinska Institute) at the 2nd DNA Replication as a Source of DNA Damage Conference in Rome, Italy between 03 and 06 July 2017.

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.

Website: https://www.fusion-conferences.com/conference67.php


July 3, 2017
July 6, 2017


Sheraton Roma Hotel & Conference Center
Rome, 00144 Italy
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